Empirical examination of the replicability of associations between brain structure and psychological variables
Year: 2019
Type: article
Study design: Observational Study
Abstract: Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported 'structural brain behavior' (SBB)-associations has been questioned, recently. Here, we conducted an empirical investigation, assessing replicability of SBB among heathy adults. For a wide range of psychological measures, the replicability of associations with gray matter volume was assessed. Our results revealed that among healthy individuals 1) finding an association between performance at standard psychological tests and brain morphology is relatively unlikely 2) significant associations, found using an exploratory approach, have overestimated effect sizes and 3) can hardly be replicated in an independent sample. After considering factors such as sample size and comparing our findings with more replicable SBB-associations in a clinical cohort and replicable associations between brain structure and non-psychological phenotype, we discuss the potential causes and consequences of these findings.
Source: eLife
DOI: 10.7554/elife.43464
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $2,398
Funders: U.S. Department of Defense, Foundation for the National Institutes of Health, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Biogen, University of Southern California, F. Hoffmann-La Roche, Meso Scale Diagnostics, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Novartis Pharmaceuticals Corporation, Northern California Institute for Research and Education, European Commission, Helmholtz-Gemeinschaft, Deutsche Forschungsgemeinschaft, Eisai, Servier, H. Lundbeck A/S, IXICO, National Institutes of Health, Genentech, Horizon 2020 Framework Programme, Canadian Institutes of Health Research, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering
Awards: G1012222616, G104586243, G1059098228, G1129793973, G1163571418, G1298807586, G1554142629, G1593117279, G1650819308, G1823308732, G1880935189, Alzheimer's Disease Neuroimaging Initiative, G2100670906, G2105457377, G2152643862, G2189010064, G2230243056, G2340207221, G2423387114, G2471646051, G2522063444, G2645940334, G2835601961, G29951154, G3130427885, G3131374986, G3146424788, G3160699921, G3216574877, G3553156159, G3705772492, G3710456697, G3752451908, G3865701414, G3870774570, G3908963977, G3966393351, Human Brain Project Specific Grant Agreement 1, G4119534169, G4175096997, G43180419, G434337789, G4401988282, G4475667458, G4501223628, G4800177743, G4860885537, G5193558347, G5207404921, G5209990037, G528601746, G5365730499, EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)", G5389965057, G5654639750, G5740349702, Human Brain Project Specific Grant Agreement 2, G5850682332, G613619302, G6173816828, G6210868510, G6371410416, G6412110892, G6447063303, G6607577419, G6719828067, G6792506723, G6899163935, G6948409098, G72415811, G7264676138, G7298697282, G7414321945, G762887596, G764699806, G7799614282, G781725486, G8228018387, G826249068, G8281378126, G839208290, G8681506169, G8852128998, G8895907669, G8897063270, G8957659042, G9000039018, G9000074849, G9000122335, G920654007
OpenAlex ID: W2949262129