Get started
Work

Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy

Year: 2019
Type: review
Abstract: Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5-15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.
DOI: 10.3390/ijms20122940
Institutions: Asia University, Chang Gung University of Science and Technology, Chang Gung Memorial Hospital, Taoyuan Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital, China Medical University, Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital
Language: English
Field: Dentistry
Open Access status: gold
Estimated APC paid: $1,824
OpenAlex ID: W2949285557
FWCI: 3.557
Cites: 166
Cited by: 313
Related to: 10