Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
Year: 2018
Type: article
Study design: Observational Study
Abstract: Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.
Source: Scientific Reports
Institutions: Åbo Akademi University, University of Turku, Turku Centre for Biotechnology, Steno Diabetes Center Copenhagen, University of Helsinki, Helsinki University Hospital, Helsinki Children's Hospital, Tampere University, Pirkanmaa Hospital District, Fimlab (Finland), University of Tampere, Turku University Hospital, Oulu University Hospital, Karolinska Institutet, University of Oulu, Örebro University, Tampere University Hospital, Folkhälsans Forskningscentrum
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,477
Awards: G4303067336, G5142293452, G6492936739
OpenAlex ID: W2795710856