Work

An efficient synthesis of hydroxyethylene dipeptide isosteres: the core unit of potent HIV-1 protease inhibitors

Year: 1991

Type: article

Abstract: from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid derived substituents.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo00023a009

Authors: Arun K. Ghosh, Sean P. McKee, Wayne J. Thompson

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS

OpenAlex ID: W2949502445

FWCI: 2.117

Cites: 15

Cited by: 63

Related to: 10