Work

Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis

Year: 2019

Type: review

Abstract: Microbial communities are complex and dynamic, composed of hundreds of taxa interacting across multiple spatial scales. Advances in sequencing and imaging technology have led to great strides in understanding both the composition and the spatial organization of these complex communities. In the human mouth, sequencing results indicate that distinct sites host microbial communities that not only are distinguishable but to a meaningful degree are composed of entirely different microbes. Imaging suggests that the spatial organization of these communities is also distinct. Together, the literature supports the idea that most oral microbes are site specialists. A clear understanding of microbiota structure at different sites in the mouth enables mechanistic studies, informs the generation of hypotheses, and strengthens the position of oral microbiology as a model system for microbial ecology in general.

Source: Annual Review of Microbiology

DOI: 10.1146/annurev-micro-090817-062503

Authors: Jessica L. Mark Welch, Floyd E. Dewhirst, Gary G. Borisy

Institutions: Marine Biological Laboratory, Harvard University, The Forsyth Institute

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Dental and Craniofacial Research

Awards: G5649142708, A Foundation for the Oral Microbiome and Metagenome, G7208149855