New Approach to the Imidazolutidine Moiety of MK-996
Year: 1996
Type: article
Abstract: A highly effective, regio-selective synthesis of imidawlutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4pentanedione.The renin-angiotensin system (RAS) is a crucial mechanism that regulate blood pressure in ~~o r m a l and pathophysiological states.'This cascade consists of two enzymes, renin and angiotensin-convening enzyme (ACE), that convert angiotensinogen to angiotensin I1 (AII).2A11 is a powerful arterial vasoconsaictor that exerts its action by interacting with specific receptors (AT1) that are present on cell membranes.One possible mode of controlling hypertension is antagonisim of the angiotensin 11 receptor3 Recently, MK-9964 was discovered to be a potent, nonpeptidic, orally active AT1-selective All antagonist.
Source: Heterocycles
DOI: 10.3987/com-95-s91
Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W2949879563