Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias
Year: 2019
Type: article
Abstract: Unexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We conclude that paradoxical lucidity, if systematically confirmed, challenges current assumptions and highlights the possibility of network-level return of cognitive function in cases of severe dementias, which can provide insight into both underlying neurobiology and future therapeutic possibilities.
Source: Alzheimer s & Dementia
Institutions: University of Michigan, RAND Corporation, International Academy of Philosophy, Pennsylvania State University, Institute for Frontier Areas of Psychology and Mental Health, Yale University, University of Virginia, University of Minnesota, University of Pennsylvania, Rush University Medical Center
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,150
Funder: National Institute on Aging
OpenAlex ID: W2950253960