Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery
Year: 1996
Type: article
Abstract: A strategic analysis of various issues which pertain to the enablement of combinatorial organic synthesis to produce libraries of non-polymeric organic molecules is given. Methods and examples of the development of solid-phase organic chemistry and its subsequent application to combinatorial library synthesis for drug discovery is illustrated with successful case studies. The synthetic versatility of resin-bound amino-acid-derived imine intermediates to produces, ?-sultams and pyridines is shown. Use of natural products as key components for creation of combinatorial libraries is presented using Rauwolfia alkaloids and the cephalosporin nucleus as examples.
Source: Accounts of Chemical Research
DOI: 10.1021/ar950170u
Authors: E. M. Gordon, M. A. Gallop, D. V. Patel
Institution: Affymax (United States)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2950429421