Year: 2017
Type: preprint
Abstract: The central nervous system is composed of many individual units -- from cells to areas -- that are connected with one another in a complex pattern of functional interactions that supports perception, action, and cognition. One natural and parsimonious representation of such a system is a graph in which nodes (units) are connected by edges (interactions). While applicable across spatiotemporal scales, species, and cohorts, the traditional graph approach is unable to address the complexity of time-varying connectivity patterns that may be critically important for an understanding of emotional and cognitive state, task-switching, adaptation and development, or aging and disease progression. Here we survey a set of tools from applied mathematics that offer measures to characterize dynamic graphs. Along with this survey, we offer suggestions for visualization and a publicly-available MATLAB toolbox to facilitate the application of these metrics to existing or yet-to-be acquired neuroimaging data. We illustrate the toolbox by applying it to a previously published data set of time-varying functional graphs, but note that the tools can also be applied to time-varying structural graphs or to other sorts of relational data entirely. Our aim is to provide the neuroimaging community with a useful set of tools, and an intuition regarding how to use them, for addressing emerging questions that hinge on accurate and creative analyses of dynamic graphs.
Source: arXiv (Cornell University)
Authors: Sizemore, Ann E., Bassett, Danielle S.
Institution: University of Pennsylvania
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2950487644