Work

A Framework for Simulating and Estimating the State and Functional Topology of Complex Dynamic Geometric Networks

Year: 2010

Type: article

Abstract: We introduce a framework for simulating signal propagation in geometric networks (networks that can be mapped to geometric graphs in some space) and developing algorithms that estimate (i.e., map) the state and functional topology of complex dynamic geometric networks. Within the framework, we define the key features typically present in such networks and of particular relevance to biological cellular neural networks: dynamics, signaling, observation, and control. The framework is particularly well suited for estimating functional connectivity in cellular neural networks from experimentally observable data and has been implemented using graphics processing unit high-performance computing. Computationally, the framework can simulate cellular network signaling close to or faster than real time. We further propose a standard test set of networks to measure performance and compare different mapping algorithms.

Source: Neural Computation

DOI: 10.1162/neco_a_00065

Authors: Marius Buibas, Gabriel A. Silva

Institution: University of California San Diego

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: G1778804830, High Throughput Mapping of Neuronal and Glial Networks