Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities
Year: 2018
Type: article
Abstract: During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women. However, understanding the underlying pathogenesis of ZIKV congenital disease has been hampered by a lack of relevant in vivo experimental models. Here we present a candidate New World monkey model of ZIKV infection in pregnant marmosets that faithfully recapitulates human disease. ZIKV inoculation at the human-equivalent of early gestation caused an asymptomatic seroconversion, induction of type I/II interferon-associated genes and proinflammatory cytokines, and persistent viremia and viruria. Spontaneous pregnancy loss was observed 16-18 days post-infection, with extensive active placental viral replication and fetal neurocellular disorganization similar to that seen in humans. These findings underscore the key role of the placenta as a conduit for fetal infection, and demonstrate the utility of marmosets as a highly relevant model for studying congenital ZIKV disease and pregnancy loss.
Source: Scientific Reports
Authors: Maxim Seferovic, Claudia Sánchez-San Martín, Suzette D. Tardif, Julienne Rutherford, Eumenia C. C. Castro, Tony Li, Vida L. Hodara, Laura M. Parodi, Luis Giavedoni, Donna Layne-Colon, Manasi Tamhankar, Shigeo Yagi, Calla Martyn, Kevin Reyes, Melissa A. Suter, Kjersti M. Aagaard, Charles Y. Chiu, Jean L. Patterson
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Blood Systems Research Institute, Texas Biomedical Research Institute, University of Oxford, National Institutes of Health, University of California, Davis, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G2211328430, Identification of diagnostic and prognostic host biomarkers of Zika virus infection by transcriptome profiling, Source of the Placental Microbiome, G4274499855, Conserved Fetal Epigenomic and Metagenomic Signatures in a Primate Model of Maternal Obesity, G9000001734, G9000052741, G9000341310, The Southwest National Primate Research Center
OpenAlex ID: W2950586202