Work

Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels

Year: 2019

Type: article

Abstract: , reduced cellular ROS levels, and increased antioxidant enzymes in old HDFs. Moreover, NecB-mediated activation of the AMPK pathway reduced intracellular ROS levels. These results suggest that NecB-induced protection against cellular senescence is mediated by ROS-scavenging through activation of AMPK. NecB might be useful in ameliorating age-related diseases and extending human lifespan.

Source: Aging

DOI: 10.18632/aging.102013

Authors: Hyun-Jin Jang, Kyeong Eun Yang, Won Keun Oh, Song-I Lee, In-Hu Hwang, Kyung-Tae Ban, Hwa-Seung Yoo, Jong-Soon Choi, Eui-Ju Yeo, Ik-Soon Jang

Institutions: Korea Basic Science Institute, Sungkyunkwan University, Seoul National University, Gachon University, Korea University, Daejeon University, Korea University of Science and Technology

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2950622326

FWCI: 1.388

Cites: 66

Cited by: 31

Related to: 10