Work

Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation

Year: 2018

Type: article

Source: The EMBO Journal

DOI: 10.15252/embj.201797931

Authors: Viet Q. Le, Roxana E. Iacob, Yuan Tian, William McConaughy, Justin Jackson, Yang Su, Bo Zhao, John R. Engen, Michelle Pirruccello-Straub, Timothy A. Springer

Institutions: Boston Children's Hospital, Harvard University, Northeastern University, Scholar Rock (United States)

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: University of Cincinnati, Susan G. Komen, National Institutes of Health, National Cancer Institute

Awards: Structural mechanisms underlying latency and activation of GDF8, G7851123907, G8764749367

OpenAlex ID: W2644729955

FWCI: 1.769

Cites: 57

Cited by: 33

Related to: 10