Work

Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy

Year: 2019

Type: article

Abstract: Autophagy is an evolutionarily conserved process that restricts certain intracellular pathogens, including HSV-1. Although HSV-1 is well known to inhibit autophagy, little is known about the precise molecular mechanisms of autophagy inhibition. We demonstrate that the Us11 protein of HSV-1 spatially disrupts the TRIM23-TBK1 complex, which subsequently suppresses autophagy and autophagy-mediated virus restriction. Thus, expression of the Us11 protein facilitates HSV-1 replication. These data unveil new insight into viral escape from autophagy-mediated host restriction mechanisms.

Source: Journal of Virology

DOI: 10.1128/jvi.00497-19

Authors: Xing Liu, Rachel Matrenec, Michaela U. Gack, Bin He

Institutions: University of Illinois Chicago, University of Chicago

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: NIH Office of the Director, National Institute of Allergy and Infectious Diseases