Year: 2018
Type: article
Abstract: Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae . As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1- positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an IS A pl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1 , and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.
Source: Nature Communications
Institutions: Peking University People's Hospital, University College London, Centre for Human Genetics, University of Oxford, Shandong Academy of Agricultural Sciences, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Peuplements végétaux et bioagresseurs en milieu tropical, University of Edinburgh, University of Cambridge, European Bioinformatics Institute, Imperial College London
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: Wellcome Trust, National Institute for Health and Care Research, Royal Society, European Commission, National Natural Science Foundation of China, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Conseil Régional de La Réunion, Medical Research Council, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, European Regional Development Fund, FP7 International Cooperation
Awards: LSI Doctoral Training Centres - CoMPLEX, Investigating the link between genome reduction and pathogenicity using an emerging zoonotic pathogen., G1394988180, G1560085021, G2063771110, G2114779333, G3023544119, G4943610202, G5331671308, G5567081764, Statistical methods for analyzing complex genomic variation in human pathogens., G6868616705, Statistical methods for analyzing complex genomic variation in human pathogens., Investigating the link between genome reduction and pathogenicity using an emerging zoonotic pathogen.
OpenAlex ID: W2770937934