Year: 2018
Type: article
Abstract: In this study, the effects of metformin onpancreatic tissue after lipopolysaccharide (LPS)-induced sepsis wereinvestigated. 30 Sprague Dawley male rats were used in the study. Five groups were formed: control, sepsis, sepsis+1 hour beforemetformin, sepsis+1 hour latermetformin and sepsis+3 hour later metformin as 6 animals in each group. LPS and metformin was prepared at 5 mg/kg and 200 mg/kgvolumes, respectively, and injected intraperitoneally to the rats. Blood samplesand pancreas tissues weretaken from the rats 24 hours after LPS injection. Amylase, glucose and insulin parameters were measured in serum of rats. Malondialdehyde (MDA)and myeloperoxidase (MPO) parameters in pancreas tissues of rats wereevaluated. Pancreatic tissueswere examined by hematoxylin-eosin (H-E) staining method histopathologically. When the results were evaluated, it was seen that LPScaused sepsis and pancreatic tissue damage in rats. However, it has beendetermined that metforminsignificantly alleviates these damages in the treatment groups. In particular, metformin administered prior to sepsis has been shown to haveprotective effects in the pancreatic tissues of rats.
Source: DergiPark (Istanbul University)
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2951161304