Effects of prenatal hypoxia on fetal sheep heart development and proteomics analysis.
Year: 2018
Type: article
Abstract: < 0.05). HE staining and electron microscopy scanning showed that the myocardium in SHG and MHG had different levels of tissue edema and abnormal distribution of mitochondrion compared to NG. Eighty differentially expressed proteins were identified in fetal cardiac tissues. In conclusion, different degrees of pregnant hypoxia sheep models were successfully established. Prenatal hypoxia can cause serious damage to heart development of fetal sheep, as well as lead to the significant changes of hypoxia-associated proteins expression, which may be used to the further investigation for clinical applications.
Source: PubMed Central
Authors: Hua Li, Jie Hu, Yibin Liu, Xianmin Wang, Sha Tang, Xinyan Chen, Ming Niu, Nusilaiti Waili, Yan Bai, Yang Wei
Institution: Xinjiang Medical University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2951163209