Year: 2019
Type: article
Abstract: BACKGROUND: Pain is a subjective experience derived from complex interactions among biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity and chronic pain prevalence are well established. However, the molecular basis underlying these sex dimorphisms are poorly understood particularly with regard to the role of the peripheral nervous system. Here we sought to identify shared and distinct gene networks functioning in the peripheral nervous systems that may contribute to sex differences of pain in rats after nerve injury. RESULTS: We performed RNA-seq on dorsal root ganglia following chronic constriction injury of the sciatic nerve in male and female rats. Analysis from paired naive and injured tissues showed that 1513 genes were differentially expressed between sexes. Genes which facilitated synaptic transmission in naïve and injured females did not show increased expression in males. CONCLUSIONS: Appreciating sex-related gene expression differences and similarities in neuropathic pain models may help to improve the translational relevance to clinical populations and efficacy of clinical trials of this major health issue.
Source: BMC Genomics
Institution: Johns Hopkins University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,145
Awards: Computational Tools for Mining Large Amounts of ChIP and Gene Expression Data, Mrgs as New Target for the Treatment of Neuropathic Pain, Developing Novel Direct Current Stimulation Technology for Safe Precision Pain Treatment, Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription, Genome-wide profiling of histone modifications associated with persistent pain, Epigenetic profiling and enzymatic regulation of H3K23me3 during cellular differentiation
OpenAlex ID: W2951274693