Year: 2017
Type: preprint
Abstract: The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body, by undertaking a Human Cell Atlas Project as an international collaborative effort. The aim would be to define all human cell types in terms of distinctive molecular profiles (e.g., gene expression) and connect this information with classical cellular descriptions (e.g., location and morphology). A comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, as well as provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas.
DOI: 10.1101/121202
Authors: Aviv Regev, Sarah A. Teichmann, Eric S. Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Göttgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Joakim Lundeberg, Partha Majumder, John C. Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe’er, Anthony Phillipakis, Chris P. Ponting, Steve Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N. Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W. Shin, Oliver Stegle, Michael Stratton, Michael J. T. Stubbington, Alexander van Oudenaarden, Allon Wagner, Fiona Watt, Jonathan Weissman, Barbara Wold, Ramnik Xavier, Nir Yosef, the Human Cell Atlas Meeting Participants
Institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University, Massachusetts Institute of Technology, European Bioinformatics Institute, University of Cambridge, Wellcome Sanger Institute, Weizmann Institute of Science, University of Zurich, RIKEN, MRC Laboratory of Molecular Biology, Molecular Immunity Unit, University Medical Center Utrecht, Princess Máxima Center, École Polytechnique Fédérale de Lausanne, University of Pennsylvania, German Cancer Research Center, Heidelberg University, Ludwig-Maximilians-Universität München, John Radcliffe Hospital, University of Oxford, MRC Human Immunology Unit, Wellcome/MRC Cambridge Stem Cell Institute, Wellcome Trust, Medical Research Council, Massachusetts General Hospital, Newcastle University, Stanford Medicine, Stanford University, NIHR Oxford Biomedical Research Centre, Medawar Building for Pathogen Research, University of California, San Francisco, Allen Institute for Brain Science, Karolinska Institutet, Science for Life Laboratory, KTH Royal Institute of Technology, National Institute of Biomedical Genomics, Cancer Research UK, Icahn School of Medicine at Mount Sinai, University of Cape Town, Institute of Infectious Disease and Molecular Medicine, University Medical Center Groningen, University of Groningen, Radboud University Nijmegen, Radboud University Medical Center, Western General Hospital, Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Edinburgh, Chan Zuckerberg Biohub San Francisco, Babraham Institute, New York Genome Center, New York University, The Netherlands Cancer Institute, Ragon Institute of MGH, MIT and Harvard, The University of Texas MD Anderson Cancer Center, Royal Netherlands Academy of Arts and Sciences, University of California, Berkeley, King's College London, California Institute of Technology, Center for Computational and Integrative Biology, Massachusetts General Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2951385940