Work

Efficiency of DNA replication in the Polymerase Chain Reactio

Year: 2001

Type: preprint

Abstract: We present a detailed kinetic model for the Polymerase Chain Reaction, and model the probability of replication in terms of the physical parameters of the problem. Applying the theory of branching processes, we show the existance of a new phenomenon affecting the probability distribution function of the number of replicants: for small number of initial molecules, the limiting behavior (with increasing number of cycles) of the pdf is represented by a multi-modal funtion.

Source: arXiv (Cornell University)

DOI: 10.48550/arxiv.cond-mat/0105099

Authors: Cecchi, Guillermo A., Stolovitzky, Gustavo

Institution: Rockefeller University

Language: English

Topic: Stochastic processes and statistical mechanics

Subfield: Mathematical Physics

Field: Mathematics

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2951782230

Cites:

Cited by: 23

Related to: 10