Work

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

Year: 2019

Type: article

Abstract: Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, we identified extensive afferent synaptic inputs to OPCs residing in secondary motor cortex, corpus callosum, and primary somatosensory cortex of adult mice. These inputs primarily arise from functionally-interconnecting cortical areas and thalamic nuclei, illustrating that OPCs have strikingly comprehensive synaptic access to brain-wide projection networks. Quantification of these inputs revealed excitatory and inhibitory components that are consistent in number across brain regions and stable in barrel cortex despite whisker trimming-induced sensory deprivation.

Source: eLife

DOI: 10.7554/elife.49291

Authors: Christopher W Mount, Belgin Yalçın, Kennedy Cunliffe-Koehler, Shree Sundaresh, Michelle Monje

Institutions: Stanford Medicine, Stanford University, Institute for Stem Cell Biology and Regenerative Medicine

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500