Work

CCR6+ B lymphocytes responding to tumor cell-derived CCL20 support hepatocellular carcinoma progression via enhancing angiogenesis.

Year: 2017

Type: article

Abstract: BACKGROUND & AIMS: mutated hepatocellular carcinoma (HCC). We aimed to understand the effect of CCL20 on HCC progression. METHODS: . H22 murine hepatoma cells were inoculated into immunocompetent or immunodeficient SCID mice, tumor growth and metastasis were monitored after the mice were treated with anti-CCL20 neutralizing antibody or depleted B cells by anti-CD20. RESULTS: . Neutralizing CCL20 activity in immunocompetent mice, not in SCID mice, attenuated tumor incidence, restrained tumor growth and distal metastasis. Tumor angiogenesis was significantly inhibited after CCL20 activity was blockade. In addition, inhibiting B lymphocyte infiltration into tumor mileum also attenuated tumor growth. CONCLUSIONS: B cells, to promote HCC progression, which might be via enhancing angiogenesis.

Source: Europe PMC (PubMed Central)

Authors: Huan He, Jianxiong Wu, Mengya Zang, Weihu Wang, Xiuli Chang, Xiangmei Chen, Ruijun Wang, Zhiyuan Wu, Liming Wang, Dongmei Wang, Fengmin Lu, Zongtang Sun, Chunfeng Qu

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, State Key Laboratory of Molecular Oncology, Peking University Cancer Hospital, Peking University

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2952346511

FWCI: 0.655

Cites: 28

Cited by: 48

Related to: 10