Work

Atom Economical, One-Pot, Three-Reaction Cascade to Novel Tricyclic 2,4-Dihydro-1H-benzo[f]isochromenes

Year: 2013

Type: article

Abstract: Reaction of 6-methyl-1-phenylhept-3-yne-2,6-diol with various aldehydes under Lewis acid conditions provides an atom economical, two-component cascade reaction sequence to novel 2,4-dihydro-1H-benzo[f]isochromene compounds. Aliphatic aldehydes as well as electron-deficient and -rich aromatic aldehydes can be used.

Source: Organic Letters

DOI: 10.1021/ol401600j

Authors: Robert J. Hinkle, Shane E. Lewis

Institution: William & Mary

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Institute of General Medical Sciences, Division of Chemistry

Awards: Bi(III)-Initiated Chemistry: Mechanistic Investigations of Catalytic Activity, G7853535145