Genome‐wide association study of peripheral blood DNA methylation and conventional mammographic density measures
Year: 2019
Type: article
Study design: Observational Study
Abstract: Age- and body mass index (BMI)-adjusted mammographie density is one the strongest breast cancer risk factors. DNA methylation is a molecular mechanism that could underlie interindividual variation in mammographic density. We aimed to investigate the association between breast cancer risk-predicting mammographic density measures and blood DNA methylation. For 436 women from the Australian Mammographic Density Twins and Sisters Study and 591 women from the Melbourne Collaborative Cohort Study, mammographic density (dense area, non-dense area and percentage dense area) defined by the conventional brightness threshold was measured using the CUMULUS software, and peripheral blood DNA methylation was measured using the HumanMethylation450 (HM450) BeadChip assay. Associations between DNA methylation at >400,000 sites and mammographic density measures adjusted for age and BMI were assessed within each cohort and pooled using fixed-effect meta-analysis. Associations with methylation at genetic loci known to be associated with mammographic density were also examined. We found no genome-wide significant( P <10 −7 )association for any mammographic density measure from the meta-analysis, or from the cohort-specific analyses. None of the 299 methylation sites located at genetic loci associated with mammographic density was associated with any mammographic density measure after adjusting for multiple testing (all P >0.05/299 = 1.7 × 10 −4 ). In summary, our study did not detect associations between blood DNA methylation, as measured by the HM450 assay, and conventional mammographic density measures that predict breast cancer risk.
Source: International Journal of Cancer
DOI: 10.1002/ijc.32171
Institutions: The University of Melbourne, University of Cambridge, Cancer Council Victoria, Monash Health, Monash University, University of Pisa, Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, The University of Western Australia, Curtin University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: A twin study of breast cancer and epigenetics, Personalized clinical genomics and epigenomics., Health 2020, Australian Centre of Excellence in Twin Research, Methylation of DNA and colorectal cancer, Methylation as a risk and prognostic factor for breast cancer, G3729156826, G4522538167, G4666353860, G4710177721, Methylation and the risk of urothelial cell cancer, G602992300, Epidemiology of Chronic Disease, Health Interventions and DNA Studies, G6713172667, G7199237069, Precision Public Health for major cancers - novel approaches to building the genetic, epigenetic and lifestyle knowledge base for assessing risk and prognosis, G734127494, Methylation as a risk factor for prostate cancer., Novel molecular markers of lung cancer risk and survival, G8030239839, G8123808567, G8797697851
OpenAlex ID: W2952515217