Year: 2013
Type: article
Abstract: We develop a system of ODEs to model the change in calcium concentration in Arbacia punctulata sperm flagella in response to chemotactic signaling. The change in calcium concentration is dependent on membrane voltage, which is in turn dependent on ion channel mechanics. We assume the ion channels can be modeled using Hodgkin-Huxley equations. We numerically solve the system of coupled non-linear ODEs and present the results for membrane voltage and calcium concentration. Experimental data, parameter estimation, and future plans to use this model to gain insight into sperm movement are discussed.
Source: Digital WPI
Author: Daniel Michael Duhaney
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2952657645