Animal Models
Year: 2019
Type: review
Abstract: At the 2018 PancreasFest meeting, experts participating in basic research met to discuss the plethora of available animal models for studying exocrine pancreatic disease. In particular, the discussion focused on the challenges currently facing the field and potential solutions. That meeting culminated in this review, which describes the advantages and limitations of both common and infrequently used models of exocrine pancreatic disease, namely, pancreatitis and exocrine pancreatic cancer. The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. The content covers both nongenic and genetically engineered models across multiple species (large and small). Recommendations for choosing the appropriate model as well as how to conduct and present results are provided.
Source: Pancreas
Institutions: University of Pittsburgh, The Ohio State University Wexner Medical Center, Cedars-Sinai Medical Center, University of California, Los Angeles, Yale University, VA Connecticut Healthcare System, University of Illinois Chicago, University of Wisconsin–Madison, Stanford University, City Of Hope National Medical Center, City of Hope, Beckman Research Institute, University of Iowa, University of Iowa Stead Family Children’s Hospital, Children's Hospital of Pittsburgh
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Neuropathic vs. inflammatory pain in chronic pancreatitis: can unique biomarkers be identified to guide mechanistic approaches to pain treatment?, Mediators of pancreatic cancer induction by alcoholic pancreatitis and smoking, Role of Growth Factors in Persistent Pain, G3311510754, Role of Lipocalin 2 in Pancreatic Cancer, Predoctoral Training in Basic Neuroscience, Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinoma, Role of Neurogenic Inflammation in Pancreatic Cancer, A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic Pancreatitis, Characterization and Plasticity of Visceral Nociceptors, PancreasFest 2018 Early Diagnosis and Treatment of Pancreatitis, Pancreatic Diabetes and Pancreatic Cancer, Exocrine pancreatic zymogen activation, G8663486456, Stearoyl-CoA Desaturase in Alcohol-Promoted Liver Tumorigenesis, UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes, Cedars Sinai Center for the Chronic Pancreatitis Clinical Research Consortium, Training in the Neurobiology of Neurological Disease, INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies, Southern California Research Center for ALPD and Cirrhosis, Precision Medicine Center for Cystic Fibrosis, Organelle Disorders in Pancreatitis
OpenAlex ID: W2952678351