Year: 2011
Type: article
Abstract: Bacterial pneumonia is a common complication of influenza A infection. We create an ODE model of bacterial infection with state variables representing the respective levels of bacteria, impaired and active neutrophils, and the anti-inflammatory molecule interleukin 10 (IL-10). After fitting the parameters, we obtain a model that demonstrates bistability between states of health and chronic bacterial infection. The fitted model also closely reproduces IL-10 data obtained from a model of mice inoculated with a strain of influenza A virus. Additionally, we develop a different model similar to the first but with stochastic intake of bacteria to represent the inhalation of small amounts of bacteria into the lungs many times daily. We find a set of parameters for which the second model produces a fit to the IAV IL-10 data.
Author: Sherry Linn
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2952694