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Epigenetic age-predictor for mice based on three CpG sites

Year: 2018
Type: article
Abstract: Epigenetic clocks for mice were generated based on deep-sequencing analysis of the methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by pyrosequencing at only three CG dinucleotides (CpGs) in the genes Prima1 , Hsf4 , and Kcns1 facilitates precise estimation of chronological age in murine blood samples, too. DBA/2 mice revealed accelerated epigenetic aging as compared to C57BL6 mice, which is in line with their shorter life-expectancy. The three-CpG-predictor provides a simple and cost-effective biomarker to determine biological age in large intervention studies with mice.
Source: eLife
DOI: 10.7554/elife.37462
Authors: Yang Han, Monika Eipel, Julia Franzen, Vadim Sakk, Bertien Dethmers-Ausema, Laura Yndriago, Ander Izeta, Gerald de Haan, Hartmut Geiger, Wolfgang Wagner
Institutions: Universitätsklinikum Aachen, RWTH Aachen University, Universität Ulm, University Medical Center Groningen, Biogipuzkoa Health Research Institute, Universidad de Navarra, Cincinnati Children's Hospital Medical Center
Language: English
Open Access status: gold
Estimated APC paid: $2,500
Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Else Kröner-Fresenius-Stiftung, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, NIH Clinical Center
Awards: G1156388270, G1854950403, G309324778, G3841898095, Verbundvorhaben: OBELICS, Epigenetik der Osteoporose, Aachen, G4058417565, G4868772416, Cdc42, hematopoietic stem cell polarity, and cell fate, G5913881499, G5983203204, Blood stem cell aging and biomarker studies, G6546718588, G8430501550
OpenAlex ID: W2796197461
FWCI: 2.31
Cites: 23
Cited by: 60
Related to: 10