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Spatiotemporally controlled nano-sized third harmonic generation agents

Year: 2019
Type: article
Abstract: Here, we present a new class of third harmonic generation (THG) imaging probes that can be activated with precise spatiotemporal control using non-linear excitation. These probes consist of lipid-coated perfluorocarbon nanodroplets with embedded visible chromophores. The droplets undergo phase transition from liquid to gas upon heating mediated by two-photon absorption of NIR light by the embedded dyes. Resulting microbubbles provide a sharp, local refractive index mismatch, which makes an excellent source of THG signal. Potential applications of these probes include activatable THG agents for biological imaging and "on-demand" delivery of various compounds under THG monitoring.
DOI: 10.1364/boe.10.003301
Institutions: The University of Texas MD Anderson Cancer Center, Far Eastern Federal University, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Cancer Genomics Centre, Rice University, The University of Texas at Austin
Language: English
Subfield: Biophysics
Open Access status: gold
Estimated APC paid: $1,913
Funders: Cancer Genomics Centre, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute, Moonshot Research and Development Program, H2020 European Research Council, Cancer Moonshot
Awards: G1468253849, G1901027039, G2690778622, G293715275, Functional, cellular, and molecular imaging and therapy monitoring using ultrasou, Center on the Physics of Cancer Metabolism, G4893957681, 3D Imaging of Tumor Mechanobiology Using Nanobomb Optical Coherence Elastography, G6736661663, G9000178996, Cancer Center Support Grant
OpenAlex ID: W2952764995
FWCI: 0.476
Cites: 78
Cited by: 11
Related to: 10