Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response
Year: 2019
Type: article
Abstract: infection (CDI) is a spore-forming anaerobic bacterium and leading cause of antibiotic-associated colitis. Epidemiological data suggest that use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk for CDI in humans, a potentially important observation given the widespread use of NSAIDs. Prior studies in rodent models of CDI found that NSAID exposure following infection increases the severity of CDI, but mechanisms to explain this are lacking. Here we present new data from a mouse model of antibiotic-associated CDI suggesting that brief NSAID exposure prior to CDI increases the severity of the infectious colitis. These data shed new light on potential mechanisms linking NSAID use to worsened CDI, including drug-induced disturbances to the gut microbiome and colonic epithelial integrity. Studies were limited to a single NSAID (indomethacin), so future studies are needed to assess the generalizability of our findings and to establish a direct link to the human condition.
Source: mBio
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: Prostaglandins as protective mediators in Clostridium difficile infection, G2887603861, A safe, targeted, designer probiotic to prevent or treat C. difficile infection, Repurposing misoprostol for Clostridium difficile colitis as identified by PheWAS, The Impact of Vancomycin-Resistant Entercoccus on Clostridium difficile Infection, The impact of dietary metals on the gut microbiome and Clostridium difficile infection, Repurposing misoprostol to prevent recurrence of Clostridium difficile infection, G9000076948, Training in Gastroenterology, Molecular and Cellular Basis for Digestive Diseases
OpenAlex ID: W2887568085