Work

Potent HIV-1 protease inhibitors: stereoselective synthesis of a dipeptide mimic

Year: 1993

Type: article

Abstract: hydroxyl configuration of the dipeptide isostere 1 is the preferred configuration for its potency. The present synthesis is efficient and provides an access to other dipeptide mimics with a great deal of structural diversity.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo00057a011

Authors: Arun K. Ghosh, Sean P. McKee, Wayne J. Thompson, Paul L. Darke, Joan C. Zugay

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS

OpenAlex ID: W2953009970

FWCI: 1.547

Cites: 11

Cited by: 40

Related to: 10