Work

SWEEPFINDER2: Increased sensitivity, robustness, and flexibility

Year: 2015

Type: preprint

Abstract: SweepFinder is a popular program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and robustness to the confounding effects of mutation rate variation and background selection, as well as increased flexibility that enables the user to examine genomic regions in greater detail and to specify a fixed distance between test sites. Moreover, SweepFinder2 enables the use of invariant sites for sweep detection, increasing both its power and precision relative to SweepFinder.

Source: arXiv (Cornell University)

DOI: 10.48550/arxiv.1505.07142

Authors: DeGiorgio, Michael, Huber, Christian D., Hubisz, Melissa J., Hellmann, Ines, Nielsen, Rasmus

Institutions: Pennsylvania State University, University of California, Los Angeles, Cornell University, Ludwig-Maximilians-Universität München, University of California, Berkeley

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2953019498

Cites: 20

Cited by: 7

Related to: 9