Work

The strategic generation and interception of palladium-hydrides for use in alkene functionalization reactions

Year: 2014

Type: article

Abstract: We review methods that our lab has developed for the generation of Pd-hydrides and the manipulation of these useful intermediates via β-hydride elimination and migratory insertion steps. For a given alkene functionalization reaction, careful understanding of the dynamics of β-hydride elimination, migratory insertion, and transmetallation have allowed for the selective functionalization of Pd-alkyl intermediates. This has afforded us a means by which to transpose palladium to a desired position on a substrate for subsequent functionalization, empowering a number of useful C–H, C–O, and C–C bond-forming reactions.

Source: Pure and Applied Chemistry

DOI: 10.1515/pac-2014-5041

Authors: Ryan J. DeLuca, Benjamin J. Stokes, Matthew S. Sigman

Institution: University of Utah

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2953022896

FWCI: 0.881

Cites: 13

Cited by: 36

Related to: 10