Work

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans

Year: 2014

Type: article

Abstract: A fundamental goal of systems neuroscience is to probe the dynamics of neural activity that drive behavior. Here we present an instrument to simultaneously manipulate neural activity via Channelrhodopsin, monitor neural response via GCaMP3, and observes behavior in freely moving C. elegans. We use the instrument to directly observe the relation between sensory stimuli, interneuron activity and locomotion in the mechanosensory circuit. Now published as: Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028

Source: eScholarship@UMassChan

Authors: Shipley, Frederick B., Clark, Christopher M., Alkema, Mark J., Leifer, Andrew M.

Institutions: Princeton University, University of Massachusetts Chan Medical School

Language: English

Topic: Photoreceptor and optogenetics research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2953085837

FWCI: 4.557

Cites: 26

Cited by: 68

Related to: 10