Work

Efficient functionalization of acylnitroso cycloadducts: Application to the syntheses of carbocyclic nucleoside precursors

Year: 1996

Type: article

Abstract: 1,4-cis-disubstituted cyclopentene precursors of carbocyclic nucleotides were readily prepared utilizing acylnitroso hetero Diels-Alder reactions and Pd(0)-catalyzed alkylation reactions as the key steps. The chemistry was explored in both racemic and asymmetric fashion. The hydroxymethyl components of the carbocyclic nucleoside precursors were obtained from nitromethyl groups under oxidative Nef conditions and may be further elaborated into a variety of compounds of potential biological interest.

Source: Tetrahedron Letters

DOI: 10.1016/0040-4039(96)00692-2

Authors: Deyi Zhang, Arun Ghosh, Carsten Süling, Marvin J. Miller

Institution: University of Notre Dame

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,610

OpenAlex ID: W2953273744

FWCI: 3.596

Cites: 21

Cited by: 29

Related to: 10