Work

Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds

Year: 2011

Type: article

Abstract: Exploration into the dienophilicity of indole in inverse electron demand Diels-Alder reactions has led to the development of the triazatetracyclo[7.7.0.0 1,13 .0 2,7]hexadeca-2,4,6,10,12-pentaene and related scaffolds for diversification in the search for new, biologically active compounds.The libraries constructed from these core structures have lead to the discovery of new anti-viral and anti-malarial compounds.

Source: Heterocycles

DOI: 10.3987/rev-11-sr(p)4

Authors: John K. Snyder, Scott C. Benson, Lily Lee, Wanguo Wei, Feng Ni, Julian David Janna Olmos, Kyle R. Strom, Aaron B. Beeler, Ken Chih-Chien Cheng, James Inglese, Smitha Kota, Virginia Takahashi, A. Donny Strosberg, John H. Connor, G. Guy Bushkin

Institutions: Boston University, National Institutes of Health, National Human Genome Research Institute, Scripps Research Institute

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W2953383606

FWCI: 0.452

Cites: 89

Cited by: 5

Related to: 10