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Effect of Vitamin D and Whole Body Vibration on HighResolution peripheral Quantitative Computed Tomography(HR-pQCT) Parameters of the Distal Tibia

Year: 2019
Type: dissertation
Study design: Clinical Trial
Abstract: Vitamin D, calcium and physical activity are important factors for bone health. A \ncross sectional study was conducted in Chapter 2 to assess vitamin D intake, \ncalcium intake and physical activity among children with wrist or ankle injuries and \ntheir association with fracture risk. The majority of children had low vitamin D and \ncalcium intake. The logistic regression indicated that there was a small but \nsignificant relationship between calcium intake and fracture risk (OR per SD \nincrease = 0.998; 95% CI, 0.997 – 0.999) but no significant relationship was found \nbetween vitamin D intake and fracture risk. \nIn the following section (Chapters 3, 4, 5 and 6), a randomised controlled trial was \nconducted to determine the effect of whole body vibration and a large single dose \nof vitamin D (150,000 IU) on bone density of the distal tibia as measured by HRpQCT. The study consisted of four parallel groups of equal numbers (40 in total); \nWBV and placebo group, placebo group, vitamin D group and vitamin D+ WBV \ngroup. Measurements (HR-pQCT, serum 25 (OH)D, PTH, bone profile) were \ncollected at baseline and after 12 weeks (during week 13). \nThe median baseline serum 25(OH)D for all participants was 23 nmol/L. The high \ndose of vitamin D was well tolerated. There was a significant increase in serum 25 \n(OH)D in vitamin D and vitamin D+WBV groups relative to the placebo group (all \np<0.01). There was a significant decrease in PTH in vitamin D group relative to the \nplacebo group (p=0.013). After 12 weeks, vitamin D group showed the greatest \nincrease in total bone density (increased by 2.7 mg/cm3 relative to the placebo \ngroup, p= 0.05). The main findings of this study indicated that the large single dose \nof vitamin D and 12 weeks of WBV did not improve bone density, bone \nmicroarchitecture or bone strength.
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2953614148
Cites: 274
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Related to: 10