Year: 2019
Type: review
Abstract: Activated macrophages play a central role in both the development and resolution of inflammation. These immune cells need to be functional in harmful conditions with high levels of reactive oxygen and nitrogen species that can damage their basic cell components, which may alter their metabolism. An excessive accumulation of these cell alterations drives macrophages inexorably to cell death, which has been associated to the development of several inflammatory diseases and even with aging in a process termed as "immunosenescence". Macrophages, however, exhibit a prolonged survival in this hostile environment because they equip themselves with a complex network of protective mechanisms. Here we provide an overview of these self-defense mechanisms with special attention being paid to bioactive lipid mediators, NRF2 signaling and metabolic reprogramming.
Source: Redox Biology
Institutions: University of Debrecen, Hungarian Academy of Sciences, Consejo Superior de Investigaciones Científicas, Instituto de Investigaciones Biomédicas Sols-Morreale, Universidad Autónoma de Madrid, Instituto de Salud Carlos III, Centro de Investigación en Red en Enfermedades Cardiovasculares, Centro de Investigación Biomédica en Red
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,850
Funders: Fundación Ramón Areces, Comunidad de Madrid, Federación Española de Enfermedades Raras, Ministerio de Economía y Competitividad, Hungarian Scientific Research Fund, Debreceni Egyetem, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Instituto de Salud Carlos III, European Regional Development Fund
Awards: G114927192, G1179170382, G1219256585, G1391975923, G184267133, G2179179329, G2298041991, G2339311647, G2511508072, G2666423252, G2681920419, G3218920753, G42952139, G4318748096, G4332340072, G4418009050, G4461279153, G5051721998, G5440016312, G579486543, G650969681, G6844982576, G7446584343, G8418255654, G997829333
OpenAlex ID: W2954019996