Work

Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.

Year: 2019

Type: article

Abstract: Purpose: ) genes. Methods: Extracellular hyperosmolarity was induced by addition of NaCl or sucrose. Gene expression was determined with real-time reverse transcription (RT)-PCR. Cytosolic interleukin-1β (IL-1β) and extracellular vascular endothelial growth factor (VEGF) levels were evaluated with enzyme-linked immunosorbent assay (ELISA). Results: genes, and blocked the NaCl-induced increase in the cytosolic IL-1β level. Conclusions: ) genes, and activation of the NLRP3 inflammasome in RPE cells.

Source: Europe PMC (PubMed Central)

Authors: Luise Messerschmidt, Sarah Fischer, Peter Wiedemann, Andreas Bringmann, Margrit Hollborn

Institutions: University Hospital Leipzig, Leipzig University

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2954037768

FWCI: 1.933

Cites: 52

Cited by: 12

Related to: 10