Work

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade

Year: 2019

Type: article

Abstract: Summary: Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of Cancer Discovery, two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition. See related article by Chen et al., p. 890. See related article by Nechiporuk et al., p. 910.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-19-0510

Authors: Michael R. Savona, Jeffrey C. Rathmell

Institutions: Vanderbilt University, Vanderbilt-Ingram Cancer Center

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute