Work

Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury

Year: 2019

Type: article

Abstract: BACKGROUND: Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke. OBJECTIVE: Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury. METHODS: After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks. RESULTS: Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery. CONCLUSIONS: These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of motor function.

Source: Restorative Neurology and Neuroscience

DOI: 10.3233/rnn-190910

Authors: T.L. Moore, B.G.E. Bowley, M.A. Pessina, S.M. Calderazzo, M. Medalla, V. Go, Z.G. Zhang, M. Chopp, S. Finklestein, A.G. Harbaugh, D.L. Rosene, B. Buller

Institutions: Boston University, Henry Ford Health, Harvard University, Massachusetts General Hospital

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, Clinical and Translational Science Institute, Boston University, National Institute on Aging, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences

Awards: Exosomes from bone marrow-derived mesenchymal stem cells as a restorative treatment in a non-human primate model of cerebral injury, G3350682876, Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity, Training in Biomolecular Pharmacology, The effect of curcumin on age-related cognitive decline in the rhesus monkey, MicroRNAs and neurogenesis after stroke, Boston University Clinical and Translational Science Institute

OpenAlex ID: W2954557808

FWCI: 1.978

Cites: 79

Cited by: 54

Related to: 10