Work

Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin

Year: 2019

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b00706

Authors: Qinghui Wang, Kinsie E. Arnst, Yuxi Wang, Gyanendra Kumar, Dejian Ma, Stephen W. White, Duane D. Miller, Weimin Li, Wei Li

Institutions: University of Tennessee Health Science Center, Sichuan University, West China Hospital of Sichuan University, St. Jude Children's Research Hospital

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: St. Jude Children's Research Hospital, National Institutes of Health, NIH Office of the Director, National Cancer Institute, National Center for Research Resources

Awards: Acquisition of a Q-TOF Mass Spectrometer, Acquisition of a 400MHz Solution NMR System with an Autosampler, G8218896238, Targeting the colchicine binding site in tubulin for cancer therapy

OpenAlex ID: W2954990356

FWCI: 4.39

Cites: 47

Cited by: 82

Related to: 10