Year: 2019
Type: report
Abstract: The objective of this project at LLNL was to test the hypothesis that naphthalene (NA) metabolites will form covalent adducts with DNA. Demonstration of NA DNA adducts drives the risk estimation because this mechanism of action is not considered to have a threshold and is tightly linked to carcinogenesis. However, proving that NA does NOT stably adduct DNA is equally important because it refocuses the studies on other mechanisms of carcinogenesis. What is critically needed, and is uniquely approachable now with new methods, is a species comparison of NA genotoxicity in the lung to provide clear data on this mode of action that is intimately related to the potential for human risk. Further, these studies provided important methodology and approaches for testing other potential DNA adducting carcinogens in the lung.
DOI: 10.2172/1529177
Authors: Bruce Buchholz, USDOE National Nuclear Security Administration (NNSA), Univ. of Arizona, Tucson, AZ (United States)
Institution: Lawrence Livermore National Laboratory
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2955021221