Knockdown of SOX12 expression inhibits the proliferation and metastasis of lung cancer cells.
Year: 2017
Type: article
Abstract: tumorigenesis experiments showed that inhibition of SOX12 expression significantly suppressed the growth of xenograft tumors. Finally, the mRNA and protein levels of cell growth (PCNA and Cyclin E), apoptosis (Bcl-2 and Bax), invasion (matrix metalloproteinase-9) and epithelial-mesenchymal transition (EMT; Twist1 and E-cadherin) related moderators were affected by SOX12 knockdown. Chromatin immunoprecipitation assays showed that Cyclin E and Twist1 were direct transcriptional targets of SOX12. Taken together, our study suggests that SOX12 functions as an oncogenic molecule during the development of human lung cancer.
Source: Europe PMC (PubMed Central)
Authors: Lei Wang, Fengqing Hu, Saie Shen, Haibo Xiao, Guoqing Li, Mingsong Wang, Ju Mei
Institutions: Shanghai Jiao Tong University, XinHua Hospital
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2955341656