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The ANKS1B Gene and its Associated Phenotypes: Focus on CNS Drug Response

Year: 2019
Type: review
Abstract: The ANKS1B gene was a top finding in genome-wide association studies (GWAS) of antipsychotic drug response. Subsequent GWAS findings for ANKS1B include cognitive ability, educational attainment, body mass index, response to corticosteroids and drug dependence. We review current human association evidence for ANKS1B, in addition to functional studies that include two published mouse knockouts. The several GWAS findings in humans indicate that phenotypically relevant variation is segregating at the ANKS1B locus. ANKS1B shows strong plausibility for involvement in CNS drug response because it encodes a postsynaptic effector protein that mediates long-term changes to neuronal biology. Forthcoming data from large biobanks should further delineate the role of ANKS1B in CNS drug response.
DOI: 10.2217/pgs-2019-0015
Language: English
Field: Medicine
Open Access status: green
Funders: Virginia Commonwealth University, National Institutes of Health, Center for Clinical and Translational Research, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: G1817255482, G1883695758, G3267869839, Network analysis of CNS transcription factors implicated in psychiatric disorders, Center for Clinical and Translational Research, G565205954, G674988631, G7454575359, G755899205, Training in Sexually Transmitted Infections and HIV
OpenAlex ID: W2955387017
FWCI: 0.253
Cites: 90
Cited by: 24
Related to: 10