Increasing the Presence of Cell Cycle Markers in Adult Cardiac Myocytes for the Treatment of Myocardial Infarction
Year: 2008
Type: article
Abstract: Myocardial infarction afflicts millions of people. Infarcted heart tissue leaves patients with dysfunctional regions of cardiac muscle, which decreases cardiac function. While multiple treatments exist, most do not restore functional myocardium. The project goal was to develop a system to co-culture cardiac myocytes with mesenchymal stem cells to promote the expression of myocyte cell cycle markers, an indication of proliferation. We have demonstrated that this co-culture system is effective in culturing two discrete cell populations that can exchange media without cell-cell contact. This yields a pure population of cells that could be delivered to the heart to replace damaged myocardium. This design may also be used to co-culture any two cell types with adaptable spatial relationships.
Source: Digital WPI
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: State University of New York
OpenAlex ID: W2955487490