Trends in Prevalence of Cardiovascular Risk Factors from 2002‐2012 among Youth Early in the Course of Type 1 and Type 2 Diabetes. The SEARCH for Diabetes in Youth Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Given diabetes is an important risk factor for cardiovascular disease (CVD), we examined temporal trends in CVD risk factors by comparing youth recently diagnosed with type 1 diabetes (T1D) and type 2 diabetes (T2D) from 2002 through 2012. METHODS: The SEARCH for Diabetes in Youth Study identified youth with diagnosed T1D (n = 3954) and T2D (n = 706) from 2002 to 2012. CVD risk factors were defined using the modified Adult Treatment Panel III criteria for metabolic syndrome: (a) hypertension; (b) high-density lipoprotein cholesterol ≤40 mg/dL; (c) triglycerides ≥110 mg/dL; and (d) waist circumference (WC) >90th percentile. Prevalence of CVD risk factors, stratified by diagnosis year and diabetes type, was reported. Univariate and multivariate logistic models and Poisson regression were fit to estimate the prevalence trends for CVD risk factors individually and in clusters (≥2 risk factors). RESULTS: The prevalence of ≥2 CVD risk factors was higher in youth with T2D than with T1D at each incident year, but the prevalence of ≥2 risk factors did not change across diagnosis years among T1D or T2D participants. The number of CVD risk factors did not change significantly in T1D participants, but increased at an annual rate of 1.38% in T2D participants. The prevalence of hypertension decreased in T1D participants, and high WC increased in T2D participants. CONCLUSION: The increase in number of CVD risk factors including large WC among youth with T2D suggests a need for early intervention to address these CVD risk factors. Further study is needed to examine longitudinal associations between diabetes and CVD.
Source: Pediatric Diabetes
DOI: 10.1111/pedi.12846
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Kaiser Permanente, Seattle Children's Research Institute, National Institutes of Health, Centers for Disease Control and Prevention, University of Colorado Denver, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Chronic Disease Prevention and Health Promotion, National Center for Advancing Translational Sciences
Awards: G1061576540, G1092462818, G1095442109, G1120840979, G1260873166, G1339932726, SEARCH FOR DIABETES IN YOUTH PHASE 3: COHORT STUDY - CALIFORNIA CENTER, G1529905483, G1536843008, G155784727, G1711565907, G1797411963, G188050375, UCHSC Diabetes and Endocrinology Research Center, Colorado Clinical and Translational Science Institute (UL1), G2080231157, G2091809135, G217027071, G22646245, G2320993242, G2429584261, G2528023306, G2588769983, G2698360221, G3013847213, G3437629819, Institute of Translational Health Sciences, G3730771870, G3783546076, G3818523422, G3861154396, G4035719383, South Carolina Clinical & Translational Research Institute (SCTR), G4085988587, G4105791890, G4282291616, G4308869390, G4458167303, G4459485335, SEARCH FOR DIABETES IN YOUTH PHASE 3: COHORT STUDY-CAROLINA CENTER, G4557776595, G4669381972, G4753745396, G486112768, G492257343, G4976965329, G5212289133, G5231222958, Center for Clinical and Translational Science and Training, G5291314479, G5452025758, G5697510622, G5962557371, G6259472129, G6600555270, G6702955718, G6880221729, G689834667, G691201058, G7155414882, G7352344800, G7546995069, G7713430636, G7887614091, G821379033, G832786732, G8637021020, G8743333551, G874743574, G884562342, G8905706376, G9000062660, G9000127314
OpenAlex ID: W2955671901