Abstract SY30-03: Desmoplastic matrices: Enablers of a synapse-like axis in pancreatic cancer
Year: 2019
Type: conference-abstract
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is predicted to soon become the second killer cancer in the USA. One of the hallmarks of PDAC is desmoplasia, which mostly consists of an expansion in activated stellate cells, known as cancer associated fibroblasts (CAFs), and remodeling of their extracellular matrix. Desmoplasia is a major culprit for the unique PDAC microenvironment; it collapses blood vessels, restricting nutrients, and fosters immunosuppression. Crosstalk between CAFs, PDAC, and immune cells, within this microenvironment, is not fully understood. This seminar will shed light on how CAF-derived matrices trigger a new signaling axis, akin to excitatory synaptic stress, responsible for CAF support of tumor cells under nutritional restriction as well as fostering pro-tumoral immunosuppression. The study identifies a novel potential target for PDAC, a cancer that is in desperate need of new and more effective therapies.Citation Format: Edna Cukierman. Desmoplastic matrices: Enablers of a synapse-like axis in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY30-03.
Source: Tumor Biology
Author: Edna Cukierman
Institution: Fox Chase Cancer Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W2955748780