Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons
Year: 2019
Type: article
Abstract: (Stem Cell Reports 11, 1211–1225; January 13, 2018) The original representative trace of excitatory post-synaptic current (EPSC) for AFF2−/y was used twice by mistake to generate the ASTN2−/y cropped trace on the top panel of Figure 5A. However, we confirm that the original data was not a duplicate; only the image file was cropped incorrectly as a display figure for the trace. We have made a new Figure 5 with the correct ASTN2 trace cropped in Figure 5A. None of the original data or interpretation of the data was impacted.Figure 5Electrophysiological Phenotyping of KO iPSC-Derived Neurons (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human NeuronsDeneault et al.Stem Cell ReportsNovember 1, 2018In BriefIn this article, Scherer and colleagues present a human induced pluripotent stem cell (iPSC) knockout resource for functional studies of ten genes associated with autism spectrum disorder. They also show that some of these genes, pertaining to diverse functional categories, can underlie common phenotypes in CRISPR-isogenic iPSC-derived glutamatergic neurons. Full-Text PDF Open Access
Source: Stem Cell Reports
Authors: Eric Deneault, Sean H. White, Deivid C. Rodrigues, P. Joel Ross, Muhammad Faheem, Kirill Zaslavsky, Zhuozhi Wang, Roumiana Alexandrova, Giovanna Pellecchia, Wei Wei, Alina Piekna, Gaganjot Kaur, Jennifer L. Howe, Vickie Kwan, Bhooma Thiruvahindrapuram, Susan Walker, Anath C. Lionel, Peter Pasceri, Daniele Merico, Ryan K.C. Yuen, Karun K. Singh, James Ellis, Stephen W. Scherer
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,800
OpenAlex ID: W2955981737