Year: 2019
Type: article
Abstract: Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (i.e., satellite cells) as well as impairs self-renewal and differentiation into muscle fibers. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor α and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females.
Source: Cell Reports
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
Funders: American Diabetes Association, Pfizer, Muscular Dystrophy Association, University of Minnesota, French Muscular Dystrophy Association, Academy of Finland, National Institutes of Health, Graduate School, University of Minnesota, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1011187029, Risk of metabolic dysfunction in middle aged women: systemic and intracrine estrogen and microRNAs as mediating factors (EsmiRs), G1628459343, G5799111648, G728849396, G8027684356, G9000136260, G9000245212, Interdisciplinary Training Program in Metabolism, Functional Multi-omics of Aging, Probing the activity of DUX4 in FSHD, Minnesota Muscle Training Program
OpenAlex ID: W2957959503